Synthesis and bio-evaluation of aryl hydrazono esters for oviposition responses in Aedes albopictus

Bioorg Med Chem Lett. 2011 Jan 15;21(2):794-7. doi: 10.1016/j.bmcl.2010.11.101. Epub 2010 Dec 4.

Abstract

A novel series of aryl hydrazono esters (AHE) (1-13) were synthesized (yield 76-98%) to study the oviposition responses in Aedes albopictus (Skuse) mosquitoes for the first time. At a concentration of 10μgml(-1) in dual choice experiment, among the screened compounds, AHE-12 showed remarkable oviposition attractant activity with an oviposition activity index (OAI) of +0.299 (greater than 95% confidence limit) comparable to p-cresol (OAI +0.320) which is well-reported oviposition attractant for Aedes aegypti. Conversely, AHE-10 exhibited highest oviposition deterrent activity with OAI -0.247. The possible utilization of these compounds will be in integrated vector management strategies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aedes / metabolism
  • Aedes / physiology*
  • Animals
  • Dengue / prevention & control
  • Esters / chemical synthesis
  • Esters / chemistry
  • Esters / metabolism
  • Female
  • Hydrazones / chemical synthesis
  • Hydrazones / chemistry*
  • Hydrazones / metabolism*
  • Oviposition*

Substances

  • Esters
  • Hydrazones