Abstract
New substituted aroylhydrazones (4a-f) were synthesized from the acid hydrazide (3) and the corresponding aldehyde or aldose. 5-Amino-4-cyano-1H-pyrazole derivatives (6a-f) were prepared by the reaction of the aroylhydrazones (4a-f) with malononitrile. The synthesized compounds were tested for antimicrobial activity against various bacteria and fungi and showed moderate to high inhibition activities. Compounds incorporating a sugar moiety as well as a pyrazolyl ring in their structure displayed the highest antimicrobial activity.
MeSH terms
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology*
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Aspergillus / drug effects
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Candida albicans / drug effects
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Hydrazones / chemical synthesis*
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Hydrazones / chemistry
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Hydrazones / pharmacology*
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Microbial Sensitivity Tests
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Molecular Structure
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Pyrazoles / chemical synthesis*
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Pyrazoles / chemistry
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Pyrazoles / pharmacology
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Quinazolinones / chemical synthesis*
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Quinazolinones / chemistry
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Quinazolinones / pharmacology*
Substances
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5-amino-4-cyano-1H-pyrazole
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Anti-Infective Agents
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Hydrazones
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Pyrazoles
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Quinazolinones