Abstract
Sixty-four of 85 (75.3%) smear-negative respiratory (n = 78) and nonrespiratory (n = 7) samples with positive cultures of Mycobacterium tuberculosis complex (MTC) were detected by the GeneXpert system using the Xpert MTB/RIF assay (GX). In addition, GX found rpoB mutations in all six of the rifampin-resistant strains detected. The test was negative in 20 culture-negative and 20 nontuberculous culture-positive samples (100% specificity). GX offers high potential for the diagnosis of tuberculosis due to its capacity for direct detection of MTC, its rapidity, and its simplicity.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / genetics*
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Bacteriological Techniques / methods*
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DNA, Bacterial / genetics
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DNA-Directed RNA Polymerases
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Drug Resistance, Bacterial
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Humans
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Mutant Proteins / genetics
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / isolation & purification*
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Polymerase Chain Reaction / methods*
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Sensitivity and Specificity
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Time Factors
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Tuberculosis / diagnosis*
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Tuberculosis / microbiology
Substances
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Bacterial Proteins
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DNA, Bacterial
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Mutant Proteins
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rpoB protein, Mycobacterium tuberculosis
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DNA-Directed RNA Polymerases