Lorcaserin, a 5-HT(2C) receptor agonist, reduces body weight by decreasing energy intake without influencing energy expenditure

J Clin Endocrinol Metab. 2011 Mar;96(3):837-45. doi: 10.1210/jc.2010-1848. Epub 2010 Dec 29.

Abstract

Context: Lorcaserin, a selective 5-hydroxytryptamine (5-HT)(2C) receptor agonist, reduces body weight. It is unclear whether weight loss is due to reduced energy intake (EI) or also to enhanced energy expenditure (EE).

Objective: This study tested the effect of lorcaserin on EI and EE.

Design, participants, and intervention: In a double-blind, randomized, placebo-controlled trial, 57 (39 women) overweight and obese (body mass index, 27-45 kg/m(2)) adults were randomized to placebo (n = 28) or 10 mg twice daily lorcaserin (n = 29) for 56 d. Weight maintenance was imposed during d 1-7. Beginning on d 8, participants followed a diet and exercise plan targeting a 600 kcal/d deficit.

Outcomes: At baseline and after 7 and 56 d of treatment, we measured body weight, body composition (dual x-ray absorptiometry), blood pressure, heart rate, EI at lunch and dinner, subjective appetite ratings, and 24-h EE and 24-h-respiratory quotient (RQ), measured by indirect calorimetry in a respiratory chamber.

Results: After 7 d of weight maintenance, EI was significantly (P < 0.01) reduced with lorcaserin but not placebo (mean ± sem for lorcaserin, -286 ± 86 kcal; placebo, -147 ± 89 kcal). After 56 d, lorcaserin resulted in significantly larger reductions in body weight (lorcaserin, -3.8 ± 0.4 kg; placebo, -2.2 ± 0.5 kg; P < 0.01), EI (lorcaserin, -470 ± 87 kcal; placebo, -205 ± 91 kcal; P < .05), and appetite ratings than in placebo. Changes in 24-h EE and 24-h RQ did not differ between groups, even after 24-h EE was adjusted for body weight and composition. Compared with placebo, lorcaserin had no effect on systolic or diastolic blood pressure or heart rate after 56 d.

Conclusions: Lorcaserin reduces body weight through reduced EI, not altered EE or RQ.

Trial registration: ClinicalTrials.gov NCT00829140.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Appetite / drug effects
  • Benzazepines / adverse effects
  • Benzazepines / pharmacology*
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Body Composition / drug effects
  • Body Mass Index
  • Body Weight / drug effects*
  • Double-Blind Method
  • Energy Intake / drug effects*
  • Energy Metabolism / drug effects*
  • Female
  • Heart Rate / drug effects
  • Heart Rate / physiology
  • Humans
  • Lipids / blood
  • Male
  • Middle Aged
  • Motor Activity / physiology
  • Obesity / drug therapy
  • Obesity / psychology
  • Overweight / drug therapy
  • Overweight / psychology
  • Oxidation-Reduction
  • Receptor, Serotonin, 5-HT2C / drug effects*
  • Serotonin Receptor Agonists / adverse effects
  • Serotonin Receptor Agonists / pharmacology*
  • Surveys and Questionnaires
  • Young Adult

Substances

  • Benzazepines
  • Lipids
  • Receptor, Serotonin, 5-HT2C
  • Serotonin Receptor Agonists
  • lorcaserin

Associated data

  • ClinicalTrials.gov/NCT00829140