Liver volume in trisomy 21 and euploid fetuses at 11 to 13 weeks

Prenat Diagn. 2011 Jan;31(1):28-32. doi: 10.1002/pd.2633.

Abstract

Objectives: To compare liver volume between trisomy 21 and euploid fetuses at 11 to 13 weeks' gestation.

Methods: Fetal liver volume was measured by 3D ultrasound in fetuses at low risk of aneuploidies (n = 200) and another group at high risk, including 148 euploid and 37 with trisomy 21. The association of liver volume with fetal nuchal translucency (NT) thickness, tricuspid regurgitation and reversed a-wave in the ductus venosus was investigated.

Results: In the low-risk group, fetal liver volume increased exponentially with fetal crown-rump length (CRL) from a median of 0.5 cm(3) at CRL of 45 mm to about 2.5 cm(3) at CRL of 84 mm. In 27 (73.0%) of the trisomy 21 fetuses liver volume was above the 95th percentile of the low-risk group, whereas in the euploid fetuses liver volume was not significantly altered (P = 0.521). There were no significant contributions to liver volume from fetal NT (P = 0.508), tricuspid regurgitation (P = 0.958) or reversed a-wave in the ductus venosus (P = 0.872).

Conclusion: In trisomy 21 fetuses at 11 to 13 weeks liver volume is increased.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Crown-Rump Length
  • Down Syndrome / diagnostic imaging*
  • Female
  • Fetal Heart / diagnostic imaging
  • Gestational Age*
  • Humans
  • Liver / diagnostic imaging*
  • Liver / embryology*
  • Nuchal Translucency Measurement
  • Pregnancy
  • Retrospective Studies
  • Tricuspid Valve Insufficiency / diagnostic imaging
  • Tricuspid Valve Insufficiency / embryology
  • Ultrasonography, Prenatal