Aim: The interrelation of adhesion between leukocyte and endothelium was studied by several irritation factors.
Methods: Leukocyte adhesion was observed by impulse electricity irritation, ischemia/reperfusion, endotoxin and IL-8 in venular of rat mesentery.
Results: The results showed these irritation factors resulted in a significant increase in the number of leukocytes adhesion along the venular endothelium of rat mesentery. IL-8 leaded to the most increase of leukocytes adhesion. Especially treated by IL-8 for 30 minutes. The number of leukocytes adhesion of the others was approximately identical.
Conclusion: The study suggests that impulse electricity irritation, ischemia/reperfusion, endotoxin and IL-8 are able to induce leukocytes and endothelium adhesion, and IL-8 of them has the most effect.