Design of an in-dwelling cannula for convection-enhanced delivery

J Neurosci Methods. 2011 Mar 15;196(1):118-23. doi: 10.1016/j.jneumeth.2010.12.022. Epub 2010 Dec 25.

Abstract

Failures of recent convection-enhanced delivery (CED) trials have underscored the need for improved CED cannulae. This study presents a novel in-dwelling cannula targeted for use in upcoming neuro-oncological or neurodegeneration trials. The cannula is reflux-resistant and easily integrated into clinical workflows. The cannula was evaluated in non-human primate CED studies performed with magnetic resonance imaging (MRI) to validate the effectiveness and safety of the infusion.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Brain / anatomy & histology
  • Catheterization / instrumentation*
  • Contrast Media / administration & dosage
  • Convection
  • Drug Delivery Systems / instrumentation*
  • Equipment Design*
  • Follow-Up Studies
  • Gadolinium
  • Heterocyclic Compounds / administration & dosage
  • Macaca mulatta
  • Magnetic Resonance Imaging
  • Organometallic Compounds / administration & dosage
  • Reproducibility of Results

Substances

  • Contrast Media
  • Heterocyclic Compounds
  • Organometallic Compounds
  • gadoteridol
  • Gadolinium