Abstract
Failures of recent convection-enhanced delivery (CED) trials have underscored the need for improved CED cannulae. This study presents a novel in-dwelling cannula targeted for use in upcoming neuro-oncological or neurodegeneration trials. The cannula is reflux-resistant and easily integrated into clinical workflows. The cannula was evaluated in non-human primate CED studies performed with magnetic resonance imaging (MRI) to validate the effectiveness and safety of the infusion.
Copyright © 2011. Published by Elsevier B.V.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Brain / anatomy & histology
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Catheterization / instrumentation*
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Contrast Media / administration & dosage
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Convection
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Drug Delivery Systems / instrumentation*
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Equipment Design*
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Follow-Up Studies
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Gadolinium
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Heterocyclic Compounds / administration & dosage
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Macaca mulatta
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Magnetic Resonance Imaging
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Organometallic Compounds / administration & dosage
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Reproducibility of Results
Substances
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Contrast Media
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Heterocyclic Compounds
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Organometallic Compounds
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gadoteridol
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Gadolinium