Macrostachyols A-D, new oligostilbenoids from the roots of Gnetum macrostachyum

Piyawit Sri-in; Jirapast Sichaem; Pongpun Siripong; Santi Tip-pyang

doi:10.1016/j.fitote.2010.12.008

Macrostachyols A-D, new oligostilbenoids from the roots of Gnetum macrostachyum

Fitoterapia. 2011 Apr;82(3):460-5. doi: 10.1016/j.fitote.2010.12.008. Epub 2010 Dec 24.

Authors

Piyawit Sri-in¹, Jirapast Sichaem, Pongpun Siripong, Santi Tip-pyang

Affiliation

¹ Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.

PMID: 21185923
DOI: 10.1016/j.fitote.2010.12.008

Abstract

Four new oligostilbenes, macrostachyols A-D (1-4) along with six known stilbenoids (5-10), were isolated from the roots of Gnetum macrostachyum. These compounds were also evaluated for their cytotoxicity towards HeLa and KB cell lines. Only compound 4 showed the significant cytotoxicity to HeLa cells with IC(50) value of 4.13 μM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Antineoplastic Agents, Phytogenic / therapeutic use
Gnetum / chemistry*
HeLa Cells
Humans
Molecular Structure
Plant Extracts / chemistry*
Plant Extracts / pharmacology
Plant Extracts / therapeutic use
Plant Roots
Stilbenes / isolation & purification*
Stilbenes / pharmacology
Stilbenes / therapeutic use

Substances

Antineoplastic Agents, Phytogenic
Plant Extracts
Stilbenes