Abstract
The blood-brain barrier (BBB) presents a significant obstacle to delivery of targeted therapies to brain tumors. In this issue of the JCI, Staquicini and colleagues apply an in vivo phage-displayed library of random peptides to identify differentially expressed peptides that can be used to transport targeted agents across the intact BBB. The authors uncover a non-canonical, peptide-mediated iron-mimicry mechanism to induce transport of the transferrin/transferrin receptor complex across the BBB. They then demonstrate the ability of phage-targeting approaches to deliver therapeutic cargo and molecular imaging reporters across the BBB in an intracranial glioblastoma mouse model.
Publication types
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Comment
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / pharmacokinetics
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Blood-Brain Barrier / drug effects*
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Blood-Brain Barrier / physiopathology
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Brain Neoplasms / drug therapy
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Brain Neoplasms / physiopathology
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Carrier Proteins / metabolism
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Disease Models, Animal
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Glioblastoma / drug therapy
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Glioblastoma / physiopathology
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Humans
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Iron / metabolism
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Mice
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Molecular Mimicry
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Peptide Library
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Receptors, Transferrin / metabolism
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Transferrin / metabolism
Substances
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Antineoplastic Agents
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Carrier Proteins
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Peptide Library
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Receptors, Transferrin
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Transferrin
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Iron