Influence of two-component signal transduction systems of Lactobacillus casei BL23 on tolerance to stress conditions

Appl Environ Microbiol. 2011 Feb;77(4):1516-9. doi: 10.1128/AEM.02176-10. Epub 2010 Dec 23.

Abstract

Lactobacillus casei BL23 carries 17 two-component signal transduction systems. Insertional mutations were introduced into each gene encoding the cognate response regulators, and their effects on growth under different conditions were assayed. Inactivation of systems TC01, TC06, and TC12 (LCABL_02080-LCABL_02090, LCABL_12050-LCABL_12060, and LCABL_19600-LCABL_19610, respectively) led to major growth defects under the conditions assayed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Tolerance / genetics
  • Gene Expression Regulation, Bacterial
  • Genes, Bacterial
  • Industrial Microbiology
  • Lacticaseibacillus casei / genetics
  • Lacticaseibacillus casei / growth & development*
  • Lacticaseibacillus casei / metabolism*
  • Microbial Sensitivity Tests
  • Mutagenesis, Insertional
  • Signal Transduction / genetics*
  • Stress, Physiological / genetics*