Biocompatible dispersions of carbon nanotubes: a potential tool for intracellular transport of anticancer drugs

Antonello Di Crescenzo; Diana Velluto; Jeffrey A Hubbell; Antonella Fontana

doi:10.1039/c0nr00444h

Biocompatible dispersions of carbon nanotubes: a potential tool for intracellular transport of anticancer drugs

Nanoscale. 2011 Mar;3(3):925-8. doi: 10.1039/c0nr00444h. Epub 2010 Dec 23.

Authors

Antonello Di Crescenzo¹, Diana Velluto, Jeffrey A Hubbell, Antonella Fontana

Affiliation

¹ Dipartimento di Scienze del Farmaco, Università G. d'Annunzio, Via dei Vestini, I-66013, Chieti, Italy.

PMID: 21180768
DOI: 10.1039/c0nr00444h

Abstract

The use of the biocompatible amphiphilic diblock copolymer poly(ethylene glycol-b-propylene sulfide) (PEG44PPS20) allows a tuned loading of doxorubicin onto the surface of non-functionalized multi-walled carbon nanotubes and an efficient cell internalization. The obtained multi-walled carbon nanotube-based systems show enhanced cytotoxic activity with respect to non-vehicled doxorubicin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / administration & dosage
Biocompatible Materials / chemical synthesis*
Breast Neoplasms / drug therapy*
Breast Neoplasms / pathology
Cell Line, Tumor
Colloids / chemical synthesis
Dose-Response Relationship, Drug
Doxorubicin / administration & dosage*
Doxorubicin / chemistry
Feasibility Studies
Humans
Nanocapsules / administration & dosage
Nanocapsules / chemistry*

Substances

Antineoplastic Agents
Biocompatible Materials
Colloids
Nanocapsules
Doxorubicin