We present the case of young women who developed celiac disease during the treatment for chronic hepatitis C. Celiac disease is now considered to be an immune disorder that is triggered by an environmental agent in genetically predisposed persons. Many studies have shown that the total prevalence of gluten sensitive-enteropathy has increased over last decades, and advances in serological screening leads to the idea that there are more celiac disease cases that are asymptomatic and undiagnosed. Actually, pegylated interferonum (IFN) in combination with ribavirine provides the most effective treatment for patient with chronic hepatitis C. However, interferon and ribavirin therapy are associated with induction or exacerbation of preexistent autoimmune disorders.