Aim: To observe the property alteration of K(v) channel in SLE patient's peripheral blood lymphocyte and its significant.
Methods: The patch-clamp technique was used to record the current of K(V) channel in SLE patient's peripheral lymphocyte.
Results: The current amplitude of K(V) channel in the SLE patient's lymphocytes decreased, it was (258.6 +/- 112.5) pA in healthy people, but in SLE patient it was (139.4 +/- 58.5) pA (P < 0.05). There was no other changes in the property of channel, include activation potential, inactivation property, channel closing kinetics and its pharmacological property.
Conclusion: The decline of SLE patient's cell immunity may be related to the decrease of the amplitude of K(V) channel current.