Aim and methods: To observe the effect of temperature on burst opening of voltage-dependent K+ channels(Kv) in hypothalamic neurons by cell-attached mode of patch-clamp technique.
Results: With temperature raising, the number of burst opening increased, so did its average burst duration. B1 and B2 raised from 1.5 ms and 6.6 ms at 32 degrees C to 8.1 ms and 83.2 ms (P < 0.05) respectively while the open number of inter-burst, from 1-2 to 8 (P < 0.05) too. Instead of SB, CB displayed predominantly a kind of burst opening.
Conclusion: More burst opening of Kv in hypothalamic neurons with temperature raising, this was benefited to the body temperature regulation of neurons on hypothalamus.