Phenalinolactones A-D, terpenoglycoside antibiotics from Streptomyces sp. Tü 6071

J Antibiot (Tokyo). 2011 Mar;64(3):229-32. doi: 10.1038/ja.2010.165. Epub 2010 Dec 22.

Abstract

Four new terpenoglycoside antibiotics, phenalinolactones A-D were isolated from Streptomyces sp. Tü 6071. The structures were elucidated on the basis of detailed NMR and MS analyses. Phenalinolactones combine a diterpenoid tricycle, a 2,3,6-trideoxysugar, a pyrrole-carboxylic acid and an uncommonly oxidized unsaturated γ-lactone in a unique manner. Phenalinolactones show an inhibitory activity against gram-positive bacteria.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Gram-Positive Bacteria / drug effects
  • Lactones / chemistry
  • Lactones / isolation & purification
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Microbial Sensitivity Tests
  • Streptomyces / metabolism*

Substances

  • Anti-Bacterial Agents
  • Diterpenes
  • Glycosides
  • Lactones
  • phenalinolactone A
  • phenalinolactone B
  • phenalinolactone C
  • phenalinolactone D