Abstract
Two serotype 19A (ST695) Streptococcus pneumoniae vaccine escape recombinant strains attributable to capsular switching events were detected by a laboratory surveillance system that is an integral part of a vaccination program begun in Liguria, Italy, in May 2003, an Italian administrative region with long-lasting high coverage, an unusual occurrence in Europe. To our knowledge, this is the first detection of an occurrence of capsular switching outside the United States.
MeSH terms
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Aged
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Aged, 80 and over
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Bacterial Capsules / immunology
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Bacterial Typing Techniques*
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Child
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Child, Preschool
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Cluster Analysis
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Communicable Diseases, Emerging / epidemiology*
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Communicable Diseases, Emerging / microbiology
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Genotype
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Heptavalent Pneumococcal Conjugate Vaccine
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Humans
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Incidence
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Infant
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Italy / epidemiology
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Microbial Sensitivity Tests
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Multilocus Sequence Typing
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Mutation*
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Pneumococcal Infections / epidemiology*
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Pneumococcal Infections / microbiology
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Pneumococcal Vaccines / immunology*
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Serotyping
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Streptococcus pneumoniae / classification*
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Streptococcus pneumoniae / genetics
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Streptococcus pneumoniae / immunology*
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Streptococcus pneumoniae / isolation & purification
Substances
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Heptavalent Pneumococcal Conjugate Vaccine
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Pneumococcal Vaccines