Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):E1-2; author reply E3-4. doi: 10.1073/iti0111108. Epub 2010 Dec 21.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Astrocytes / metabolism*
  • Cells, Cultured
  • Gene Expression Regulation, Enzymologic / drug effects
  • Gene Expression Regulation, Enzymologic / physiology*
  • Heme Oxygenase (Decyclizing) / metabolism
  • Hydrogen Peroxide / pharmacology
  • Ischemic Preconditioning
  • NF-E2-Related Factor 2 / metabolism*
  • Neurons / metabolism*
  • Neuroprotective Agents / metabolism*
  • Oxidative Stress / physiology*
  • Oxidoreductases Acting on Sulfur Group Donors / metabolism
  • Rats

Substances

  • NF-E2-Related Factor 2
  • Neuroprotective Agents
  • Nfe2l2 protein, rat
  • Hydrogen Peroxide
  • Heme Oxygenase (Decyclizing)
  • Hmox1 protein, rat
  • Oxidoreductases Acting on Sulfur Group Donors
  • Srxn1 protein, rat