Schinarisanlactone A, a new bisnortriterpenoid from Schisandra arisanensis

Yu-Chi Lin; I-Wen Lo; Shun-Ying Chen; Pi-Han Lin; Ching-Te Chien; Sui-yuan Chang; Ya-Ching Shen

doi:10.1021/ol102772j

Schinarisanlactone A, a new bisnortriterpenoid from Schisandra arisanensis

Org Lett. 2011 Feb 4;13(3):446-9. doi: 10.1021/ol102772j. Epub 2010 Dec 22.

Authors

Yu-Chi Lin¹, I-Wen Lo, Shun-Ying Chen, Pi-Han Lin, Ching-Te Chien, Sui-yuan Chang, Ya-Ching Shen

Affiliation

¹ School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.

PMID: 21175150
DOI: 10.1021/ol102772j

Abstract

A novel triterpenoid, schinarisanlactone A (1), was isolated from the fruits of Schisandra arisanensis. Compound 1 possesses an unprecedented skeleton having a 5/7/7/5/7/5/6/5-fused octacyclic ring system. The structure of 1 was determined by 2D NMR techniques (COSY, HMQC, HMBC, and NOESY) and was confirmed by X-ray crystallographic analysis. Schinarisanlactone A (1) exhibited significant anti-HIV activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-HIV Agents / chemistry
Anti-HIV Agents / isolation & purification*
Anti-HIV Agents / pharmacology
Crystallography, X-Ray
Fruit / chemistry
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Schisandra / chemistry*
Taiwan
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / pharmacology

Substances

Anti-HIV Agents
Triterpenes
schinarisanlactone A