Abstract
The highly enantioselective synthesis of 2-aryl- and 2-vinyl-piperidines has been accomplished through a catalytic dynamic resolution (CDR) of N-Boc-2-lithiopiperidine. The method has been applied to the synthesis of both enantiomers of the tobacco alkaloid anabasine.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alkaloids / chemical synthesis*
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Alkaloids / chemistry
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Anabasine / chemical synthesis*
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Anabasine / chemistry
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Catalysis
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Molecular Structure
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Nicotiana / chemistry
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Organometallic Compounds / chemistry*
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Piperidines / chemical synthesis*
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Piperidines / chemistry
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Stereoisomerism
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Vinyl Compounds / chemical synthesis*
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Vinyl Compounds / chemistry
Substances
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Alkaloids
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N-Boc-2-lithiopiperidine
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Organometallic Compounds
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Piperidines
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Vinyl Compounds
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Anabasine