DNA replication: making two forks from one prereplication complex

Michael Botchan; James Berger

doi:10.1016/j.molcel.2010.12.014

DNA replication: making two forks from one prereplication complex

Mol Cell. 2010 Dec 22;40(6):860-1. doi: 10.1016/j.molcel.2010.12.014.

Authors

Michael Botchan¹, James Berger

Affiliation

¹ Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. mbotchan@berkeley.edu

Abstract

The copying of chromosomal DNA initiates from a single nucleoprotein assembly called the prereplication complex. New findings in a recent issue of Molecular Cell (Yardimci et al., 2010) reveal that this complex dissolves into two independent replisomes that move away from each other as DNA synthesis ensues.

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