Late ovarian hyperstimulation syndrome after controlled ovarian stimulation in a woman with systemic lupus erythematosus and lupus nephritis

Abstract

Objective: To report a case of late ovarian hyperstimulation syndrome (OHSS) in a woman with lupus nephritis undergoing controlled ovarian stimulation and in vitro fertilization (IVF) with subsequent transfer into a gestational surrogate.

Design: A case report.

Setting: Academic reproductive medicine clinic.

Patient(s): A 33-year-old woman who presented 10 days after recombinant human chorionic gonadotropin (hCG) injection with fatigue, abdominal pain, and bloating, diagnosed as OHSS.

Intervention(s): Patient admitted for intravenous fluid hydration, anticoagulation, and gonadotropin-releasing hormone (GnRH) antagonist therapy.

Main outcome measure(s): Successful detection and management of severe OHSS in a patient with chronically impaired kidney function.

Result(s): The patient has returned to her baseline condition, and the gestational carrier was noted to have a twin gestation.

Conclusion(s): In patients with impaired renal function, final oocyte maturation should be triggered with a GnRH agonist rather than hCG.