[The characteristics of opioid receptors distributed in the neurons of habenula]

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2005 Feb;21(1):64-7.
[Article in Chinese]

Abstract

Aim: To explore the types of receptors distributed in MHb and LHb.

Methods: Recording the currents of potassium channels in Hb neurons isolated from the rats 10-15 days after birth. To distinguish the types of receptors distributed in MHb and LHb by using the agonists of mu receptor DAMGO, and sigma receptor DPDPE.

Results: Two types of current of K+ channels were recorded, the transient rectifier and delayed rectifier potassium channels. DAMGO or DPDPE increased the intensity of current of K+ channels.

Conclusion: In MHb there was a higher density of sigma receptor, and in LHb a higher density of mu receptor distributed.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Animals, Newborn
  • Habenula / metabolism*
  • Neural Pathways
  • Neurons / metabolism*
  • Potassium Channels / metabolism
  • Rats
  • Receptors, Opioid / metabolism*

Substances

  • Potassium Channels
  • Receptors, Opioid