Effects of human defensin-α(1)on Trypanosoma cruzi trypomastigotes in vitro

Bull Exp Biol Med. 2010 Nov;149(6):731-3. doi: 10.1007/s10517-010-1038-5.

Abstract

Human defensin-α(1)is a biologically active peptide exhibiting a dose-dependent trypanocidal effect in vitro against trypomastigotes and amastigotes of Trypanosoma cruzi line Tulahuen. This effect is determined by fragmentation of parasite DNA reducing the capacity of passaged T. cruzi to invade HeLa cells.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Defensins / chemistry
  • Defensins / physiology*
  • Humans
  • In Vitro Techniques
  • Molecular Sequence Data
  • Trypanosoma cruzi / physiology*

Substances

  • Defensins
  • insect defensin A