Drug discovery: How melanomas bypass new therapy

MeSH terms

• Drug Resistance, Neoplasm* / drug effects
• Drug Resistance, Neoplasm* / genetics
• Enzyme Activation / drug effects
• Extracellular Signal-Regulated MAP Kinases / metabolism
• Gene Expression Regulation, Neoplastic / drug effects
• Humans
• Indoles / pharmacology
• Indoles / therapeutic use
• MAP Kinase Kinase Kinases / genetics
• MAP Kinase Kinase Kinases / metabolism*
• MAP Kinase Signaling System* / drug effects
• Melanoma / drug therapy*
• Melanoma / enzymology*
• Melanoma / genetics
• Melanoma / pathology
• Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors
• Mitogen-Activated Protein Kinase Kinases / metabolism
• Mutation / genetics
• Neoplasm Recurrence, Local
• Protein Kinase Inhibitors / pharmacology
• Protein Kinase Inhibitors / therapeutic use
• Proto-Oncogene Proteins / genetics
• Proto-Oncogene Proteins / metabolism*
• Proto-Oncogene Proteins B-raf / antagonists & inhibitors*
• Proto-Oncogene Proteins B-raf / chemistry
• Proto-Oncogene Proteins B-raf / genetics
• Proto-Oncogene Proteins B-raf / metabolism
• Proto-Oncogene Proteins c-raf / genetics*
• Proto-Oncogene Proteins c-raf / metabolism
• Sulfonamides / pharmacology
• Sulfonamides / therapeutic use
• Vemurafenib