GNRA/receptor interacting modules: versatile modular units for natural and artificial RNA architectures

Junya Ishikawa; Yuki Fujita; Yuri Maeda; Hiroyuki Furuta; Yoshiya Ikawa

doi:10.1016/j.ymeth.2010.12.011

GNRA/receptor interacting modules: versatile modular units for natural and artificial RNA architectures

Methods. 2011 Jun;54(2):226-38. doi: 10.1016/j.ymeth.2010.12.011. Epub 2010 Dec 14.

Authors

Junya Ishikawa¹, Yuki Fujita, Yuri Maeda, Hiroyuki Furuta, Yoshiya Ikawa

Affiliation

¹ Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Fukuoka 819-0395, Japan.

PMID: 21163353
DOI: 10.1016/j.ymeth.2010.12.011

Abstract

Interactions between GNRA tetraloops and their receptors are found frequently as modular units in various types of naturally occurring structured RNAs. Due to their functional importance, GNRA/receptor interactions have been studied extensively with regard to their 3D structures and biochemical and biophysical properties. Artificial non-natural GNRA/receptor modules have also been generated not only to obtain a better understanding of this class of motifs in natural RNA structures but also for application of these modular units to the design and construction of artificial RNA structures that can be used as platforms to generate functional RNAs applicable for nanobiotechnology. In this review, we present a survey of structures, functions, and analyses as well as artificial generation and application of GNRA/receptor interacting modules.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Base Sequence
Magnesium / chemistry
Nucleic Acid Conformation*
RNA / chemistry*
RNA, Catalytic / chemistry

Substances

RNA, Catalytic
RNA
Magnesium