Primary cutaneous anaplastic large-cell lymphoma

Dermatol Online J. 2010 Nov 15;16(11):2.

Abstract

Primary cutaneous anaplastic large-cell lymphoma (ALCL) is a form of cutaneous T-cell lymphoma that is characterized by solitary or localized nodules or plaques. Histopathologic features include a diffuse, non-epidermotropic infiltrate with cohesive sheets of large anaplastic CD30+ tumor cells. This entity must be distinguished from systemic ALCL with cutaneous involvement and lymphomatoid papulosis. Treatment modalities include clinical monitoring, radiation therapy, and surgical excision, with systemic chemotherapy reserved for disseminated or extracutaneous disease.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Combined Modality Therapy
  • Humans
  • Ki-1 Antigen / metabolism
  • Lymphoma, Primary Cutaneous Anaplastic Large Cell / diagnosis*
  • Lymphoma, Primary Cutaneous Anaplastic Large Cell / pathology
  • Lymphoma, Primary Cutaneous Anaplastic Large Cell / radiotherapy
  • Lymphoma, Primary Cutaneous Anaplastic Large Cell / surgery
  • Male
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / radiotherapy
  • Skin Neoplasms / surgery
  • Treatment Outcome

Substances

  • Ki-1 Antigen