[44-year-old woman with elevated liver enzymes and a family history for cholelithiasis]

Internist (Berl). 2011 Oct;52(10):1234-7. doi: 10.1007/s00108-010-2775-2.
[Article in German]

Abstract

"Low phospholipid associated cholelithiasis" (LPAC) syndrome is an important differential diagnosis in younger patients with biliary symptoms after cholecystectomy and concomitant elevated serum liver tests. Typical symptoms include recurrence of biliary colics after cholecystectomy, echogenic material in the intrahepatic bile ducts, intrahepatic cholestasis of pregnancy or cholestasis under hormonal contraception and a family history of gallstone disease. Patients with LPAC syndrome can be successfully treated with ursodeoxycholic acid.

Publication types

  • Case Reports

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B / genetics
  • Adult
  • Alanine Transaminase / blood*
  • Alleles
  • Aspartate Aminotransferases / blood*
  • Bile Duct Diseases / diagnosis*
  • Bile Ducts, Intrahepatic*
  • Cholangiopancreatography, Endoscopic Retrograde
  • Cholecystectomy*
  • Cholelithiasis / diagnosis*
  • Cholelithiasis / genetics*
  • Cholelithiasis / surgery
  • Colic / etiology
  • Female
  • Genetic Carrier Screening
  • Humans
  • Liver Function Tests*
  • Pedigree
  • Phospholipids / deficiency*
  • Point Mutation / genetics
  • Postcholecystectomy Syndrome / diagnosis*
  • Postcholecystectomy Syndrome / etiology
  • Syndrome
  • Ultrasonography
  • gamma-Glutamyltransferase / blood*

Substances

  • ATP Binding Cassette Transporter, Subfamily B
  • Phospholipids
  • multidrug resistance protein 3
  • gamma-Glutamyltransferase
  • Aspartate Aminotransferases
  • Alanine Transaminase