Evaluation of the expression of isoforms of stem cell factor mRNA in fetal tissues and mononuclear cells at different stages of human development

V A Sadovskaya; S V Sennikov; G V Seledtsova; A N Silkov; V A Kozlov

doi:10.1007/s10517-010-1085-y

Evaluation of the expression of isoforms of stem cell factor mRNA in fetal tissues and mononuclear cells at different stages of human development

Bull Exp Biol Med. 2010 Dec;150(1):122-4. doi: 10.1007/s10517-010-1085-y.

Authors

V A Sadovskaya¹, S V Sennikov, G V Seledtsova, A N Silkov, V A Kozlov

Affiliation

¹ Research Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. sadovskayavera@ngs.ru

PMID: 21161069
DOI: 10.1007/s10517-010-1085-y

Abstract

We studied the expression of isoforms of stem cells factor mRNA forming as a result of alternative splicing. Both isoforms of stem cell factor mRNA forming as a result of alternative splicing were found in different fetal tissues. Changes in the expression of alternative isoforms of stem cell factor in peripheral blood mononuclear cells were demonstrated from the prenatal and neonatal periods to adult organism.

MeSH terms

Adult
Alternative Splicing / genetics
Alternative Splicing / physiology
Female
Fetus / metabolism*
Humans
In Vitro Techniques
Leukocytes, Mononuclear / metabolism*
Polymerase Chain Reaction
Pregnancy
Protein Isoforms / metabolism*
Stem Cell Factor / metabolism*
Young Adult

Substances

Protein Isoforms
Stem Cell Factor