Inhibition of norepinephrine reuptake and size of myocardial infarction during focal ischemia and after preconditioning

S E Naumenko; T V Latysheva; M A Gilinskii

doi:10.1007/s10517-010-1056-3

Inhibition of norepinephrine reuptake and size of myocardial infarction during focal ischemia and after preconditioning

Bull Exp Biol Med. 2010 Dec;150(1):15-7. doi: 10.1007/s10517-010-1056-3.

Authors

S E Naumenko¹, T V Latysheva, M A Gilinskii

Affiliation

¹ Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. NSE2@mail.ru

PMID: 21161040
DOI: 10.1007/s10517-010-1056-3

Abstract

Experiments on rats showed that blockade of norepinephrine reuptake in the early reperfusion period after focal myocardial ischemia aggravates myocardial injury and abolishes the protective effect of ischemic preconditioning.

MeSH terms

Animals
Desipramine / pharmacology*
Ischemic Preconditioning, Myocardial*
Male
Myocardial Infarction / metabolism*
Myocardial Ischemia / metabolism*
Norepinephrine / antagonists & inhibitors
Norepinephrine / metabolism*
Random Allocation
Rats
Rats, Wistar

Substances

Desipramine
Norepinephrine