Abstract
4-Hydroxycordoin (1), a natural isopentenyloxychalcone, is a plant secondary metabolite that is relatively rare. Since there are very few reports about the biological activities of 1, its potential benefits for periodontal disease were investigated. A marked and dose-dependent antibacterial activity of 1 was observed against the three major periodontal pathogens, Porphyromonas gingivalis, Fusobacterium nucleatum, and Prevotella intermedia. Moreover, compound 1 showed an antiadhesion effect, since it inhibited attachment of P. gingivalis to oral epithelial cells. Finally, using a macrophage model, the ability of 1 to inhibit the secretion of inflammatory mediators induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide was demonstrated. The anti-inflammatory effect observed was associated with reduced activation of the nuclear factor-κB (NF-κB) p65 and activator protein-1 (AP-1) pathways.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Chalcones / chemistry
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Chalcones / isolation & purification*
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Chalcones / pharmacology*
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Dinoprostone / analysis
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Dinoprostone / metabolism
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Dose-Response Relationship, Drug
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Fabaceae / chemistry
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Humans
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Models, Biological
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Molecular Structure
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Periodontal Diseases / drug therapy*
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Periodontal Diseases / microbiology
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Replication Protein C / drug effects
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Transcription Factor RelA / drug effects
Substances
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4-hydroxycordoin
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Anti-Bacterial Agents
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Anti-Inflammatory Agents
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Chalcones
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Lipopolysaccharides
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Transcription Factor RelA
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Replication Protein C
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Dinoprostone