Here we give an overview of the past and ongoing research in the biology of ageing in Spain. Some of the main topics being investigated are those related to oxidative stress and aging. One of the main findings is the implication of mitochondria in the age-associated oxidative stress. Nutritional modulation of aging is another topic which has been dealt with, and one of the main findings is that methionine restriction has a role in longevity extension. Regarding to hormones and aging, is important to highlight the role of estrogens in protecting females against oxidative stress, and the health-associated effects of melatonin. Finally, molecular biologists have found new age-associated genes by showing changes in longevity of genetically manipulated mice.