Abstract
Vinyl, aryl, and alkynyl organometallics add to ketones containing a stereogenic sulfoxide. Tertiary alcohols are generated in diastereomerically and enantiomerically pure form. Reductive lithiation converts the sulfoxide into a variety of useful functional groups.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Benzyl Alcohols / chemical synthesis*
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Benzyl Alcohols / chemistry
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Catalysis
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Combinatorial Chemistry Techniques
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Ketones / chemistry*
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Lithium / chemistry
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Molecular Structure
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Organometallic Compounds / chemistry
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Stereoisomerism
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Sulfoxides / chemistry*
Substances
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Benzyl Alcohols
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Ketones
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Organometallic Compounds
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Sulfoxides
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Lithium