Water-soluble peptide-coated nanoparticles: control of the helix structure and enhanced differential binding to immune cells

Iria M Rio-Echevarria; Regina Tavano; Valerio Causin; Emanuele Papini; Fabrizio Mancin; Alessandro Moretto

doi:10.1021/ja107588q

Water-soluble peptide-coated nanoparticles: control of the helix structure and enhanced differential binding to immune cells

J Am Chem Soc. 2011 Jan 12;133(1):8-11. doi: 10.1021/ja107588q. Epub 2010 Dec 10.

Authors

Iria M Rio-Echevarria¹, Regina Tavano, Valerio Causin, Emanuele Papini, Fabrizio Mancin, Alessandro Moretto

Affiliation

¹ Dipartimento di Scienze Chimiche, Università di Padova, via Marzolo 1, 35131 Padova, Italy.

PMID: 21142034
DOI: 10.1021/ja107588q

Abstract

The stabilizing action of C(α)-tetrasubstituted α-amino acids inserted into a sequence of short peptides allowed for the first time the preparation of water-soluble nanoparticles of different materials coated with a helix-structured undecapeptide. This peptide coating strongly favors nanoparticle uptake by human immune system cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

HeLa Cells
Humans
Immune System / cytology*
Macrophages / metabolism
Models, Molecular
Monocytes / metabolism
Nanoparticles / chemistry*
Peptides / chemistry*
Peptides / metabolism*
Protein Binding
Protein Structure, Secondary
Siloxanes / chemistry
Solubility
Substrate Specificity
Water / chemistry*

Substances

Peptides
Siloxanes
ormosil
Water