Asymmetric dimethylarginine in ELBW newborns exposed to chorioamnionitis

Michela Alfiero Bordigato; Daniele Piva; Iole Maria Di Gangi; Giuseppe Giordano; Lino Chiandetti; Marco Filippone

doi:10.1016/j.earlhumdev.2010.11.004

Asymmetric dimethylarginine in ELBW newborns exposed to chorioamnionitis

Early Hum Dev. 2011 Feb;87(2):143-5. doi: 10.1016/j.earlhumdev.2010.11.004. Epub 2010 Dec 8.

Authors

Michela Alfiero Bordigato¹, Daniele Piva, Iole Maria Di Gangi, Giuseppe Giordano, Lino Chiandetti, Marco Filippone

Affiliation

¹ Neonatal Intensive Care Unit, Dept. of Pediatrics, University of Padova, Italy. michela.alfierobordigato@unipd.it

PMID: 21138787
DOI: 10.1016/j.earlhumdev.2010.11.004

Abstract

We measured circulating ADMA concentrations in a group of very premature newborns at birth and during the first week of life. ADMA levels resulted significantly higher in infants born to mothers with histologic chorioamnionitis than in infants delivered for other maternal or fetal indications, both at birth and through the first week of life. We speculate that ADMA might be involved in the complex biological events associated with fetal exposure to chorioamnionitis.

MeSH terms

Arginine / analogs & derivatives*
Arginine / analysis
Arginine / blood
Chorioamnionitis* / blood
Chorioamnionitis* / pathology
Female
Gestational Age
Humans
Infant, Extremely Low Birth Weight / blood*
Infant, Newborn
Male
Osmolar Concentration
Pregnancy
Prenatal Exposure Delayed Effects / blood
Prenatal Exposure Delayed Effects / immunology
Prenatal Exposure Delayed Effects / pathology

Substances

N,N-dimethylarginine
Arginine