Aim: To investigate the effects of different anesthesia and analgesia on erythrocyte immune function of patients with ovarian benign tumor treated by laparoscopic therapeutic.
Methods: 120 patients with ovarian benign tumor treated by laparoscopic therapeutic were randomly divided into two groups with 60 cases each.In group A, patients received general anesthesia eombined with thoracic epidural anesthesia during surgery, patients in group B received general anesthesia. The cervical venous blood samples were obtained at the following time points: before induction of anesthesia(T0), 30 min after anesthesia (T1), 1 h during operation (T2), 24 h after operation (T3), 48 h after operation (T4) and 72 h after operation (T5).RRCR, RRICR and RTRR were measured at different time points.
Results: RRCR, RRICR and RTRR in two groups decreased significantly from T1(P<0.05). RRCR in two groups was on the low-water mark at T4 and RRICR, RTRR was on the low-water mark at T3.There were no significantly different of RRCR, RRICR and RTRR in two groups at T0. There were significantly different of RRCR, RRICR and RTRR in two groups from T1 to T4(P<0.05), the increase in group A was less than that in group B(P<0.05).
Conclusion: Anesthesia may harm on erythroeyte immune function of patients with ovarian benign tumor treated by laparoscopic therapeutic. The effect of general anesthesia combined with thoraeic epidural anesthesia on erythrocyte immune function was less.