Abstract
A fluoroquinolone (FQ) resistance rate of 5.9% is reported in 205 Mycobacterium tuberculosis isolates from patients presenting to field clinics in Karachi, Pakistan (2006 to 2009). FQ resistance among multidrug-resistant (MDR) strains was 11.1% (5/45), and it was 4.9% (5/103) in M. tuberculosis strains susceptible to all first-line agents. Spoligotyping of resistant strains did not show dominance of one strain type. Our data reflect considerable FQ-resistant M. tuberculosis isolates and the need to consider inclusion of FQ within first-line sensitivity testing in such settings.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ambulatory Care Facilities / statistics & numerical data
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Antitubercular Agents / pharmacology*
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Bacterial Typing Techniques
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Drug Resistance, Multiple, Bacterial* / genetics
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Fluoroquinolones / pharmacology*
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Humans
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / classification
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / genetics
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Oligonucleotides / analysis
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Pakistan / epidemiology
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Tuberculosis, Multidrug-Resistant / epidemiology*
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Tuberculosis, Multidrug-Resistant / microbiology
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Tuberculosis, Pulmonary / epidemiology*
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Tuberculosis, Pulmonary / microbiology
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Urban Population
Substances
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Antitubercular Agents
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Fluoroquinolones
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Oligonucleotides