Tuberculosis is becoming a more prominent pediatric disease, but there are few recent reports of endobronchial involvement. We have presented the case of a 4-month-old infant with symptomatic obstructive airway disease due to Mycobacterium tuberculosis. Endobronchial tuberculosis usually follows 2 to 3 months of antituberculous therapy. This case is especially unusual because the endobronchial disease developed before diagnosis or therapy. Endobronchial tuberculosis should be considered in any patient with symptoms or roentgenographic findings of obstructive airway disease. Bronchoscopy is the best technique for diagnosis and follow-up of endobronchial tuberculosis.