Cardiac arrhythmia: a simple conceptual framework

Trends Cardiovasc Med. 2010 Apr;20(3):103-7. doi: 10.1016/j.tcm.2010.09.003.

Abstract

This review presents a simple trigger-substrate model of arrhythmogenesis and its application to the generation of reentrant ventricular arrhythmias. We demonstrate its broad applicability to the understanding of arrhythmic phenomena in a wide range of both hereditary and acquired arrhythmic disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Animals
  • Arrhythmias, Cardiac / etiology*
  • Arrhythmias, Cardiac / physiopathology
  • Heart Conduction System / physiopathology*
  • Humans
  • Risk Factors
  • Time Factors