'2+1' tricarbonyltechnetium(I)/tricarbonylrhenium(I) mixed-ligand complexes with methyl thiosalicylate and isocyanide ligands as potential precursors of radiopharmaceuticals

Abstract

The complexes of [(99m)Tc]-tricarbonyltechnetium(I) and [(188)Re]-tricarbonylrhenium(I), of the '2+1' type, with methyl thiosalicylate as an anionic bidentate ligand and with either tert-butyl 3-isocyanopropionate or glycine-glycine-tyrosine 4-isocyanobutyrate as monodentate ligands, have been prepared on the n.c.a. scale. The complexes exhibit different lipophilicity and high stability in neutral aqueous solutions. Based on the results of the challenge experiment with histidine, cysteine and glutathione the studied complexes might be considered to be promising models for radiopharmaceutical precursors.