Abstract
Phytochemical study of the leaves and stems of Calea zacatechichi Schl. (Asteraceae) led to the isolation of a series of six germacranolides (1-6) with significant antileishmanial activity. The structure of a new compound named by us as calealactone D (1) was determined by NMR and MS, and its absolute configuration by X-ray crystallography. In addition, calealactone E (5) was discovered as a new naturally occurring compound, and the absolute configuration of calealactone C (2) was also determined by X-ray crystallography. All compounds were biologically evaluated in antimicrobial and antiprotozoal assays.
© Georg Thieme Verlag KG Stuttgart · New York.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Anti-Bacterial Agents / pharmacology
-
Antifungal Agents / pharmacology
-
Antiprotozoal Agents / chemistry
-
Antiprotozoal Agents / isolation & purification
-
Antiprotozoal Agents / pharmacology
-
Asteraceae / chemistry*
-
Chromatography, High Pressure Liquid
-
Crystallography, X-Ray
-
Humans
-
Lactones / chemistry
-
Lactones / isolation & purification
-
Lactones / pharmacology
-
Microbial Sensitivity Tests
-
Plant Components, Aerial / chemistry
-
Plant Extracts / chemistry
-
Plant Extracts / isolation & purification
-
Plant Extracts / pharmacology
-
Sesquiterpenes, Germacrane / chemistry
-
Sesquiterpenes, Germacrane / isolation & purification*
-
Sesquiterpenes, Germacrane / pharmacology*
Substances
-
Anti-Bacterial Agents
-
Antifungal Agents
-
Antiprotozoal Agents
-
Lactones
-
Plant Extracts
-
Sesquiterpenes, Germacrane
-
germacranolide