Two new acetylated flavan glycosides from rhizomes of the fern Abacopteris penangiana

J Asian Nat Prod Res. 2010 Dec;12(12):1015-9. doi: 10.1080/10286020.2010.525744.

Abstract

Two new acetylated flavan glycosides (2S,4R)-4,5,7-trihydroxy-4'-methoxy-6,8-dimethylflavan-5-O-β-D-6-acetylglucopyranoside-7-O-β-D-glucopyranoside (1) and (2S,4R)-5,7-dihydroxy-4,4'-dimethoxy-6,8-dimethylflavan-5-O-β-D-6-acetylglucopyranoside-7-O-β-D-glucopyranoside (2) were isolated from the rhizomes of Abacopteris penangiana. Their structures were elucidated on the basis of spectroscopic methods including IR, HR-ESI-MS, 1D and 2D NMR, and chemical evidences.

MeSH terms

  • Acetylation
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Ferns / chemistry*
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification*
  • Flavonoids / pharmacology
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Glucosides / pharmacology
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Hep G2 Cells
  • Humans
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Rhizome / chemistry

Substances

  • (2S,4R)-4,5,7-trihydroxy-4'-methoxy-6,8-dimethylflavan-5-O-beta-D-6-acetylglucopyranoside-7-O-beta-D-glucopyranoside
  • (2S,4R)-5,7-dihydroxy-4,4'-dimethoxy-6,8-dimethylflavan-5-O-beta-D-6-acetylglucopyranoside-7-O-beta-D-glucopyranoside
  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Flavonoids
  • Glucosides
  • Glycosides