Remotely nano-rupturable yolk/shell capsules for magnetically-triggered drug release

Chem Commun (Camb). 2011 Feb 14;47(6):1776-8. doi: 10.1039/c0cc03998e. Epub 2010 Dec 2.

Abstract

Yolk/shell capsules containing a volume/hydrophobicity transformable core and an ultra-thin silica shell have been prepared. When an external magnetic field induced the temperature, the cores exhibit a significant triggering size shrinkage and the diameter decreases more than 10 times, causing solid shells destruction and physical collapse, leading to drug burst release.

MeSH terms

  • Coated Materials, Biocompatible / administration & dosage
  • Coated Materials, Biocompatible / analysis*
  • Coated Materials, Biocompatible / chemistry
  • Electromagnetic Phenomena*
  • Ferric Compounds / chemistry
  • Hydrophobic and Hydrophilic Interactions
  • Microscopy, Electron, Scanning
  • Microscopy, Electron, Transmission
  • Nanocapsules / administration & dosage
  • Nanocapsules / analysis*
  • Nanocapsules / chemistry
  • Nanoparticles / chemistry
  • Silicon Dioxide / chemistry*
  • Temperature

Substances

  • Coated Materials, Biocompatible
  • Ferric Compounds
  • Nanocapsules
  • ferric oxide
  • Silicon Dioxide