Pulmonary aspergillosis caused by a pan-azole-resistant Aspergillus fumigatus in a 10-year-old boy

Pediatr Infect Dis J. 2011 Mar;30(3):268-70. doi: 10.1097/INF.0b013e3182037879.

Abstract

A 10-year-old boy with high-risk acute lymphoblastic leukemia treated with hematopoietic stem-cell transplantation developed pulmonary aspergillosis while receiving prophylactic voriconazole. A transpleural aspirate culture revealed a pan-azole-resistant Aspergillus fumigatus. Treatment with liposomal amphotericin B resulted in complete recovery. As the frequency of azole resistance in A. fumigatus increases, invasive procedures to isolate fungi for species identification and susceptibility testing becomes even more important.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / administration & dosage
  • Antifungal Agents / pharmacology*
  • Aspergillus fumigatus / drug effects*
  • Aspergillus fumigatus / isolation & purification*
  • Azoles / administration & dosage
  • Azoles / pharmacology*
  • Chemoprevention / methods
  • Child
  • Drug Resistance, Multiple, Fungal*
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Male
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Pulmonary Aspergillosis / diagnosis*
  • Pulmonary Aspergillosis / drug therapy
  • Pulmonary Aspergillosis / microbiology*
  • Pyrimidines / administration & dosage
  • Treatment Outcome
  • Triazoles / administration & dosage
  • Voriconazole

Substances

  • Antifungal Agents
  • Azoles
  • Pyrimidines
  • Triazoles
  • liposomal amphotericin B
  • Amphotericin B
  • Voriconazole