Increased activity of circulating polymorphonuclear leukocytes in acute myocardial infarction

M Radomski; K Herbaczyńska-Cedro; L Ceremuzyński

doi:10.1016/0167-5273(90)90300-t

Increased activity of circulating polymorphonuclear leukocytes in acute myocardial infarction

Int J Cardiol. 1990 Jun;27(3):392-3. doi: 10.1016/0167-5273(90)90300-t.

Authors

M Radomski¹, K Herbaczyńska-Cedro, L Ceremuzyński

Affiliation

¹ Medical Research Centre, Polish Academy of Sciences, Warsaw.

PMID: 2112517
DOI: 10.1016/0167-5273(90)90300-t

Abstract

Acute myocardial infarction results in an increased sensitivity of circulating polymorphonuclear leukocytes to ex vivo aggregation. This increase was prevented by pretreatment of leukocytes with BW755, but not with aspirin, suggesting that the activation of blood leukocytes in infarction is due to a stimulation of cellular lipoxygenase.

MeSH terms

4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine / pharmacology
Adult
Aspirin / pharmacology
Cell Aggregation / drug effects
Female
Humans
In Vitro Techniques
Male
Middle Aged
Myocardial Infarction / blood*
Neutrophils / drug effects
Neutrophils / physiology*

Substances

4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
Aspirin