Abstract
Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)(4) (12b) and NDGA-(triazol-glucose)(4) (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.
Copyright © 2010. Published by Elsevier Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / therapeutic use
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Carcinoma, Hepatocellular / drug therapy
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Cell Line, Tumor
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Galactosides / chemical synthesis
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Galactosides / chemistry*
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Galactosides / therapeutic use
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Glucosides / chemical synthesis
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Glucosides / chemistry*
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Glucosides / therapeutic use
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Glycosylation
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Humans
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Liver Neoplasms / drug therapy
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Masoprocol / analogs & derivatives*
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Masoprocol / chemical synthesis
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Masoprocol / chemistry*
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Masoprocol / therapeutic use
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Triazoles / chemical synthesis
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Triazoles / chemistry
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Triazoles / therapeutic use
Substances
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Antineoplastic Agents
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Galactosides
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Glucosides
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Triazoles
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Masoprocol