Glycosylated nordihydroguaiaretic acids as anti-cancer agents

Bioorg Med Chem Lett. 2011 Jan 1;21(1):380-2. doi: 10.1016/j.bmcl.2010.10.137. Epub 2010 Oct 31.

Abstract

Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)(4) (12b) and NDGA-(triazol-glucose)(4) (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / therapeutic use
  • Carcinoma, Hepatocellular / drug therapy
  • Cell Line, Tumor
  • Galactosides / chemical synthesis
  • Galactosides / chemistry*
  • Galactosides / therapeutic use
  • Glucosides / chemical synthesis
  • Glucosides / chemistry*
  • Glucosides / therapeutic use
  • Glycosylation
  • Humans
  • Liver Neoplasms / drug therapy
  • Masoprocol / analogs & derivatives*
  • Masoprocol / chemical synthesis
  • Masoprocol / chemistry*
  • Masoprocol / therapeutic use
  • Triazoles / chemical synthesis
  • Triazoles / chemistry
  • Triazoles / therapeutic use

Substances

  • Antineoplastic Agents
  • Galactosides
  • Glucosides
  • Triazoles
  • Masoprocol