Abstract
Thiosemicarbazones display a wide antimicrobial activity by targeting bacteria, fungi, and viruses. Here, we report our studies on the antiviral activity of two thiosemicarbazone metal complexes, [bis(citronellalthiosemicarbazonato)nickel(II)] and [aqua(pyridoxalthiosemicarbazonato)copper(II)] chloride monohydrate, against the retroviruses HIV-1 and HTLV-1/-2. Both compounds exhibit antiviral properties against HIV but not against HTLVs . In particular, the copper complex shows the most potent anti-HIV activity by acting at the post-entry steps of the viral cycle.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacology
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Anti-Retroviral Agents / chemical synthesis*
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Anti-Retroviral Agents / chemistry
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Anti-Retroviral Agents / pharmacology
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Cell Survival
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Coordination Complexes / chemical synthesis*
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology
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HIV-1 / drug effects*
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HIV-1 / physiology
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Human T-lymphotropic virus 1 / drug effects*
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Human T-lymphotropic virus 1 / physiology
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Human T-lymphotropic virus 2 / drug effects*
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Human T-lymphotropic virus 2 / physiology
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Humans
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In Vitro Techniques
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Leukocytes, Mononuclear / drug effects
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Leukocytes, Mononuclear / virology
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Structure-Activity Relationship
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Thiosemicarbazones / chemical synthesis*
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Thiosemicarbazones / chemistry
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Thiosemicarbazones / pharmacology
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Virus Internalization
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Virus Replication / drug effects
Substances
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Anti-HIV Agents
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Anti-Retroviral Agents
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Coordination Complexes
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Thiosemicarbazones
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aqua(pyridoxalthiosemicarbazonato)copper(II)
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bis(citronellalthiosemicarbazonato)nickel(II)