Positive results of usage of sub atmospheric pressure in therapy of acute and chronic wounds in vascular patients are presented in many works of contemporary surgeons and vascular specialists. Negative pressure wound therapy (NPWT, vacuum sealing) found its broad utilization in vascular surgery. Despite the fact, that in the last years was the indication of this therapy in prevention and therapy of vascular graft infections discussed many times, are works dealing with this topic still rare. Our case document, that under certain circumstances can negative pressure wound therapy be used also in this indications. Though there were surprising results achieved in our cases, we think, that these patients after a successful NPWT need a long-term follow up. To prove the efficacy of vacuum sealing in therapy of vascular graft infections needs in our opinion further observation and studies.