Seroprevalence survey of Chikungunya virus in Bagan Panchor, Malaysia

Am J Trop Med Hyg. 2010 Dec;83(6):1245-8. doi: 10.4269/ajtmh.2010.10-0279.

Abstract

In 2006, an outbreak of Chikungunya virus (CHIKV) of the Asian genotype affected over 200 people in Bagan Panchor village in Malaysia. One year later, a post-outbreak survey was performed to determine attack rate, asymptomatic rate, and post-infection sequelae. Findings were compared with recent CHIKV outbreaks of the Central/East African genotype. A total of 180 residents were interviewed for acute symptoms and post-infection physical quality of life and depressive symptoms. Sera from 72 residents were tested for CHIKV neutralizing antibodies. The estimated attack rate was 55.6%, and 17.5% of infected residents were asymptomatic. Arthralgia was reported up to 3 months after infection, but there were no reports of long-term functional dependence or depression. Symptomatic and seropositive residents were significantly more likely to live in the area with the most dense housing and commercial activities. CHIKV had a high attack rate and considerable clinical impact during the Bagan Panchor outbreak.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Alphavirus Infections / epidemiology
  • Chikungunya Fever
  • Chikungunya virus / genetics
  • Chikungunya virus / isolation & purification*
  • Child
  • Child, Preschool
  • Disease Outbreaks
  • Female
  • Genotype
  • Humans
  • Infant
  • Malaysia / epidemiology
  • Male
  • Middle Aged
  • Seroepidemiologic Studies
  • Young Adult