Background: It is unclear whether endogenous serotonin release is involved in the regulation of gastric motility and food intake.
Aim: To study the effect of acute administration of the selective serotonin reuptake inhibitor citalopram on gastric motor function in man.
Methods: Nineteen healthy volunteers underwent a gastric barostat, gastric emptying and/or a drinking test after dosing with either placebo or citalopram (20 mg intravenously). In the barostat protocol, a flaccid bag was introduced in the stomach and inflated at intra-abdominal pressure +2 mmHg, volume was recorded before and after administration of a liquid meal (300 kcal). Gastric emptying for solids and liquids was simultaneously assessed using the ¹⁴C-octanoic acid/¹³C-glycine breath test. During the drink test, volunteers drank at a rate of 15 mL/min until maximal satiation. Citalopram was compared with placebo using t-tests and mixed model analysis.
Results: Citalopram induced a significant preprandial gastric relaxation (volume increase of 154 ± 55 mL vs. -38 ± 33 mL after placebo dosing; P < 0.05), whereas the postprandial volume increase was significantly decreased after citalopram treatment (F₁₂.₈₀ = 4.78, P < 0.0001; maximum volume increase was 304 ± 40 vs. 201 ± 54 mL after placebo and citalopram treatment respectively). Citalopram enhanced solid (123 ± 17 vs. 77 ± 6 min, P < 0.05) but not liquid emptying (62 ± 6 vs. 57 ± 4 min). Satiation scores during the drink test were lower after citalopram (F₁₉.₁₅₃ = 2.02, P = 0.01; volunteers drank 998 ± 129 vs. 765 ± 79 mL after citalopram and placebo treatment respectively).
Conclusion: The observed effects indicate a role for serotonin in the control of gastric motility and food intake.
© 2010 Blackwell Publishing Ltd.