Abstract
Aim of this study was to assess clinical and pharmacoeconomic effects of long term use of adrenoblockers in patients with ischemic heart disease (IHD) undergoing coronary artery bypass grafting. Patients with IHD (n=294) were included in open, prospective, randomized clinical trial. The follow up period was 3 years. It was noted that long term use of bisoprolol in comparison with atenolol and metoprolol was characterized by more pronounced increase of exercise tolerance, lower rate of angina recurrence and lower expenses for treatment of patients with IHD.
Publication types
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English Abstract
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Randomized Controlled Trial
MeSH terms
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Adrenergic beta-1 Receptor Antagonists / administration & dosage
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Adrenergic beta-1 Receptor Antagonists / adverse effects
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Angina Pectoris / diagnosis
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Angina Pectoris / economics
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Angina Pectoris / physiopathology
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Angina Pectoris / therapy*
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Atenolol / administration & dosage
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Atenolol / adverse effects
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Bisoprolol* / administration & dosage
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Bisoprolol* / adverse effects
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Comparative Effectiveness Research
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Coronary Angiography
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Coronary Artery Bypass / methods*
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Cost Savings*
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Exercise Test / drug effects*
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Female
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Graft Occlusion, Vascular / prevention & control*
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Humans
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Male
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Metoprolol / administration & dosage
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Metoprolol / adverse effects
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Middle Aged
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Patient Readmission
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Time
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Treatment Outcome
Substances
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Adrenergic beta-1 Receptor Antagonists
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Atenolol
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Metoprolol
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Bisoprolol